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Content of the deep dive

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What is Hepatitis B disease?

Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It is a major global health problem. It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer. It can be fatal if it is not treated. There is still limited access to diagnosis and treatment of hepatitis B in many resource-constrained settings.

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Our in silico project workflow

NOVA's approach combines mathematical models of diseases and treatments with virtual patients into an integrated clinical trial simulation platform Jinkō®, in 6 stages: the problem formulation, the systemic knowledge review, the computational models, the calibration, the model validation and the simulation.

 

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Hepatitis B deep dive

The purpose of this case study is to showcase the standard workflow of a modeling & simulation project NOVA undertook in HBV. Our HBV model was developed to explore drug candidate efficacy of an FXR agonist on HBV chronic infection and to optimize the design of a Phase 2 trial with the potential treatment.