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Content of the case study


What is Myocardial reperfusion injury?

A myocardial infarction (MI), also known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw.


Our in silico project workflow

NOVA's approach combines mathematical models of diseases and treatments with virtual patients into an integrated clinical trial simulation platform Jinkō®, in 6 stages: the problem formulation, the systemic knowledge review, the computational models, the calibration, the model validation and the simulation.



Myocardial reperfusion injury case study

The purpose of this case study is to detail the standard workflow of a modeling & simulation project. Applied to myocardial reperfusion injury this in silico clinical trial shows the efficacy of the inhibition of reactive oxygen species production in ST elevated myocardial infarction.