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Content of the case study

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What is Myocardial reperfusion injury?

A myocardial infarction (MI), also known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw.

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Our in silico project workflow

NOVA's approach combines mathematical models of diseases and treatments with virtual patients into an integrated clinical trial simulation platform Jinkō®, in 6 stages: the problem formulation, the systemic knowledge review, the computational models, the calibration, the model validation and the simulation.

 

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Myocardial reperfusion injury case study

The purpose of this case study is to detail the standard workflow of a modeling & simulation project. Applied to myocardial reperfusion injury this in silico clinical trial shows the efficacy of the inhibition of reactive oxygen species production in ST elevated myocardial infarction.